- Early Detection of Leptospirosis in Human
Leptospirosis is a zoonotic
disease with a worldwide distribution. The disease manifestations might
range from mild, subclinical to a severe potentially fatal. Since mild,
uncharacteristic signs and symptoms of fever, headache and muscle pain
often are confused with other likely disease that are not recognized
and reported as leptospirosis, the number of mild cases is unknown.
Recent estimates on severe leptospirosis, with complications such as
hepatorenal failure and (lung)haemorrhagic complaints mostly requiring
hospitalization, indicate 1 million cases annually, about 60,000
running a fatal cause, presenting a burden of Around 3 million DALYs.
- Epidemiology of Leptospirosis in Cattle
We are considering a SIVR model
of Leptospirosis for livestock cows. Since Leptospirosis has diferent
consequences for juvenile and adult cows, we prefer to have an age
structured model. Imagine a hypothetical farm in which juvenile and
adult cows live together and they are gathered up every six months in
order to vaccine and count them. All the animals are vaccinated no
matter whether they are infected or healthy. The farm management wants
to keep the number of animals in the farm constant as possible as, so
new juvenile cows are brought into the farm every six months to adjust
for diseases death. The infection occur through contact with infected
animals, or through environment with urine from shedding infected cows.