Seminars and Colloquiums
for the week of January 18, 2010
Speaker:
Professor Peter Kim, University of Utah, Thursday
Thursday, January 21
COLLOQUIUM
TIME: 3:35 4:25 p.m.
ROOM: HBB 102
SPEAKER: Professor Peter Kim, University of Utah
TITLE: Role of regulatory T cells in producing a robust immune response and
maintaining immunodominance.
ABSTRACT: Several theories exist concerning primary T cell responses, the most
prevalent being that T cells follow developmental programs. We propose the alternative
hypothesis that the response is governed by a feedback loop between conventional
and adaptive regulatory T cells (iTregs). By developing a mathematical model,
we show that the regulated response is robust to a variety of parameters and
propose that T cell responses may be governed by emergent group dynamics rather
than by autonomous programs.
We extend this model to show how T cell regulation may apply to immunodominance.
Immunodominance refers to the phenomenon in which simultaneous T cell responses
organize themselves into clear hierarchies. We extend our model of T cell regulation
to consider multiple, concurrent T cell responses. Using our model, we show
that iTreg-mediated regulation leads to a hierarchical expansion of T cell responses
as observed in the phenomenon of immunodominance.
If you are interested in giving or arranging a talk for one of our seminars or colloquiums, please review our calendar.
If you have questions, or a date you would like to confirm, please contact Dr. Steve Wise.
Week of:
Past notices:
Seminars from 2008-2009 academic year
Seminars from 2007-2008 academic year
Seminars from 2006-2007 academic year